Augmented Dissection

Dissection has long been the primary method to gain greater insight into the structures and functions of the human body. It requires careful step-by-step analysis, retrieval of stored information, and spatial navigation to successfully explore our inner makings. Many facilities and campuses nationwide are not equipped for cadavers, and in particular, online laboratory settings are often devoid of hands-on dissection altogether. Anatomy 4D is an augmented reality (AR) mobile application that allows for human body exploration through enhanced dissection. Its application in laboratory settings may be a viable means of resolving hands-on dissection limitations. To investigate this idea, college anatomy students utilized the AR mobile application to dissect the heart organ in an action research study. Students performed activities individually, by creating personalized deliverables to share, and collaboratively, by contemplating connections through discussion. In better determining the impact of AR dissection in enhancing identification of human body structures among learners, pre and post assessments were conducted. Overall results indicated AR utilization for human organ exploration was positive with a marked increase of recognition after lesson activities and numerous indications of personal satisfaction from the use of mobile learning technology, constructivist design, and peer collaboration

Investigating the direct and indirect associations between birth intervals and child growth and development: a cross-sectional analysis of 13 Demographic and Health Surveys

There is considerable literature on the associations of short birth intervals with adverse perinatal outcomes. However, less is known about the associations with child growth and development. In this study, we investigated the associations between birth intervals and child growth and development and examined child illness, child diet, and maternal stimulation as potential mechanisms. We pooled Demographic and Health Survey data on 8300 children aged 36–59 months from 13 countries (Benin, Burundi, Cambodia, Cameroon, Chad, Congo, Haiti, Honduras, Rwanda, Senegal, Timor-Leste, Togo, and Uganda). Longer birth interval was defined as a preceding birth interval ≥33 months. Child growth was assessed using height-for-age Z-score (HAZ). Child cognitive and socio-emotional development were measured using the Early Childhood Development Index. Child morbidity was defined as any illness in the past two weeks. Child diet was assessed using dietary diversity score and maternal stimulation by the number of stimulation activities. We used generalised linear models to estimate associations between longer birth intervals and child growth and development. Structural equation modelling was used to assess direct and indirect effects. In our sample, 44% of children had a preceding birth interval ≥33 months, 42% were stunted, 25% were cognitively off-track, and 33% socio-emotionally off-track. Longer birth intervals were associated with higher HAZ (mean difference 0.23 (95% CI 0.14, 0.32)) and socio-emotional development (relative risk (RR) 1.04 (95% CI 1.00, 1.09), but not cognitive development (RR 1.02 (95% CI 0.98, 1.06). We observed no significant indirect effects via child illness, child dietary diversity, or maternal stimulation. Although longer birth intervals were beneficial for child growth and socio-emotional development, we found no empirical support for the biological and behavioural mechanisms we explored. Additional research is needed to investigate alternative mechanisms to elucidate underlying processes and inform future interventions

Maternal and paternal employment in agriculture and early childhood development: a cross-sectional analysis of Demographic and Health Survey data

Considerable literature from low- and lower-middle-income countries (LLMICs) links maternal employment to child nutritional status. However, less is known about the role of parental employment and occupation type in shaping child development outcomes. Additionally, little empirical work has examined the mechanisms through which parental occupation influences child outcomes. Our objective was to investigate the associations between maternal and paternal employment (comparing agricultural and non-agricultural employment) and child development and to examine childcare practices and women's empowerment as potential mechanisms. We pooled nine Demographic and Health Surveys (Benin, Burundi, Cambodia, Congo, Haiti, Rwanda, Senegal, Togo, and Uganda) with data on 8,516 children aged 36-59 months. We used generalised linear models to estimate associations between parental employment and child development, child stimulation (number of activities provided by the mother, father, and other household members), child supervision (not left alone or with older child for >1 hour), early childhood care and education programme (ECCE) attendance, and women's empowerment. In our sample, all fathers and 85% of mothers were employed. In 40% of families, both parents were employed in agriculture. After adjusting for child, parental and household confounders, we found that parental agricultural employment, relative to non-agricultural employment, was associated with poorer child development (relative risk (RR) 0.86 (95% CI 0.80, 0.92), more child stimulation provided by other household members (mean difference (MD) 0.26 (95% CI 0.09, 0.42)), less adequate child supervision (RR, 0.83 (95% 0.78, 0.80)), less ECCE attendance (RR 0.46 (95% CI 0.39, 0.54)), and lower women's empowerment (MD -1.01 (95% CI -1.18, -0.84)). Parental agricultural employment may be an important risk factor for early childhood development. More research using more comprehensive exposure and outcome measures is needed to unpack these complex relationships and to inform interventions and policies to support working parents in the agricultural sector with young children

Evaluating and Securing Text-Based Java Code through Static Code Analysis

As the cyber security landscape dynamically evolves and security professionals work to keep apace, modern-day educators face the issue of equipping a new generation for this dynamic landscape. With cyber-attacks and vulnerabilities substantially increased over the past years in frequency and severity, it is important to design and build secure software applications from the group up. Therefore, defensive secure coding techniques covering security concepts must be taught from beginning computer science programming courses to exercise building secure applications. Using static analysis, this study thoroughly analyzed Java source code in two textbooks used at a collegiate level, with the goal of guiding educators to make a reference of the resources in teaching programming concepts from a security perspective. The resources include the methods of source code analysis and relevant tools, categorized bugs detected in the code, and compliant code examples with fixing the bugs. Overall, the first text revealed a relatively moderate bug rate of approximately 44% of files analyzed contained either regular or security bugs. About 13% of the total bugs found were security bugs and the most common security bug was related to the Pseudo Random security vulnerability. The second text produced a slightly larger bug rate of 53.80% with approximately 8% of security bugs. After combining the texts for an average rate, the total number of security bugs that were likely to appear was roughly 10% percent. This encompasses security bugs such as malicious code vulnerabilities and security vulnerabilities related to exposing or manipulating data in these programs

A rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of Salmonella.

Bacterial pathogens causing systemic disease commonly evolve from organisms associated with localized infections but differ from their close relatives in their ability to overcome mucosal barriers by mechanisms that remain incompletely understood. Here we investigated whether acquisition of a regulatory gene, tviA, contributed to the ability of Salmonella enterica serotype Typhi to disseminate from the intestine to systemic sites of infection during typhoid fever. To study the consequences of acquiring a new regulator by horizontal gene transfer, tviA was introduced into the chromosome of S. enterica serotype Typhimurium, a closely related pathogen causing a localized gastrointestinal infection in immunocompetent individuals. TviA repressed expression of flagellin, a pathogen associated molecular pattern (PAMP), when bacteria were grown at osmotic conditions encountered in tissue, but not at higher osmolarity present in the intestinal lumen. TviA-mediated flagellin repression enabled bacteria to evade sentinel functions of human model epithelia and resulted in increased bacterial dissemination to the spleen in a chicken model. Collectively, our data point to PAMP repression as a novel pathogenic mechanism to overcome the mucosal barrier through innate immune evasion

Biologically and acoustically compatible chamber for studying ultrasound-mediated delivery of therapeutic compounds

Ultrasound (US), in combination with microbubbles, has been found to be a potential alternative to viral therapies for transfecting biological cells. The translation of this technique to the clinical environment, however, requires robust and systematic optimization of the acoustic parameters needed to achieve a desired therapeutic effect. Currently, a variety of different devices have been developed to transfect cells in vitro, resulting in a lack of standardized experimental conditions and difficulty in comparing results from different laboratories. To overcome this limitation, we propose an easy-to-fabricate and cost-effective device for application in US-mediated delivery of therapeutic compounds. It comprises a commercially available cell culture dish coupled with a silicon-based "lid" developed in-house that enables the device to be immersed in a water bath for US exposure. Described here are the design of the device, characterization of the sound field and fluid dynamics inside the chamber and an example protocol for a therapeutic delivery experiment

Modelling of self-similar teletraffic for simulation

Recent studies of real teletraffic data in modern computer networks have shown that teletraffic exhibits self-similar (or fractal) properties over a wide range of time scales. The properties of self-similar teletraffic are very different from the traditional models of teletraffic based on Poisson, Markov-modulated Poisson, and related processes. The use of traditional models in networks characterised by self-similar processes can lead to incorrect conclusions about the performance of analysed networks. These include serious over-estimations of the performance of computer networks, insufficient allocation of communication and data processing resources, and difficulties ensuring the quality of service expected by network users. Thus, full understanding of the self-similar nature in teletraffic is an important issue. Due to the growing complexity of modern telecommunication networks, simulation has become the only feasible paradigm for their performance evaluation. In this thesis, we make some contributions to discrete-event simulation of networks with strongly-dependent, self-similar teletraffic. First, we have evaluated the most commonly used methods for estimating the self-similarity parameter H using appropriately long sequences of data. After assessing properties of available H estimators, we identified the most efficient estimators for practical studies of self-similarity. Next, the generation of arbitrarily long sequences of pseudo-random numbers possessing specific stochastic properties was considered. Various generators of pseudo-random self-similar sequences have been proposed. They differ in computational complexity and accuracy of the self-similar sequences they generate. In this thesis, we propose two new generators of self-similar teletraffic: (i) a generator based on Fractional Gaussian Noise and Daubechies Wavelets (FGN-DW), that is one of the fastest and the most accurate generators so far proposed; and (ii) a generator based on the Successive Random Addition (SRA) algorithm. Our comparative study of sequential and fixed-length self-similar pseudo-random teletraffic generators showed that the FFT, FGN-DW and SRP-FGN generators are the most efficient, both in the sense of accuracy and speed. To conduct simulation studies of telecommunication networks, self-similar processes often need to be transformed into suitable self-similar processes with arbitrary marginal distributions. Thus, the next problem addressed was how well the self-similarity and autocorrelation function of an original self-similar process are preserved when the self-similar sequences are converted into suitable self-similar processes with arbitrary marginal distributions. We also show how pseudo-random self-similar sequences can be applied to produce a model of teletraffic associated with the transmission of VBR JPEG /MPEG video. A combined gamma/Pareto model based on the application of the FGN-DW generator was used to synthesise VBR JPEG /MPEG video traffic. Finally, effects of self-similarity on the behaviour of queueing systems have been investigated. Using M/M/1/∞ as a reference queueing system with no long-range dependence, we have investigated how self-similarity and long-range dependence in arrival processes affect the length of sequential simulations being executed for obtaining steady-state results with the required level of statistical error. Our results show that the finite buffer overflow probability of a queueing system with self-similar input is much greater than the equivalent queueing system with Poisson or a short-range dependent input process, and that the overflow probability increases as the self-similarity parameter approaches one

“His mind will work better with both of us”: A qualitative study on fathers’ roles and coparenting of young children in rural Pakistan

Background: Parents are the primary providers of nurturing care for young children’s healthy early development. However, the literature on parenting in early childhood, especially in low- and middle-income countries, has primarily focused on mothers. In this study, we investigate how parents make meaning of fathers’ parenting roles with regards to their young children’s early health and development in rural Pakistan.Methods: Data were collected between January and March 2017 through in-depth interviews with fathers (N = 33) and their partners (N = 32); as well as separate focus group discussions with fathers (N = 7) and mothers (N = 7). Data were analyzed using thematic content analysis.Results: Parents described a distinct division of roles between fathers and mothers; and also several shared caregiving roles of fathers and mothers. Specifically, parents highlighted aspects of fathers’ coparenting and several common ways by which fathers supported their partners. We found that these gendered divisions in parenting roles were strongly embedded within a complex network of interacting factors across the individual, family, and sociocultural contexts of the study community.Conclusions: Our findings suggest a more family-centered conceptualization of fatherhood during early childhood that encompasses both fathers’ direct engagement with their young children and their indirect contributions through coparenting, while recognizing a variety of contextual systems that shape paternal parenting. Future parenting interventions that reflect the lived experiences of both fathers and mothers as parents and partners may further enhance the nurturing care environments that are critical for promoting healthy early child development

Associations between birth registration and early child growth and development: evidence from 31 low- and middle-income countries

Background: Lack of legal identification documents can impose major challenges for children in low- and middle-income countries (LMICs). The aim of this study was to investigate the association between not having a birth certificate and young children’s physical growth and developmental outcomes in LMICs. Methods: We combined nationally representative data from the Multiple Indicator Cluster Surveys in 31 LMICs. For our measure of birth registration, primary caregivers reported on whether the child had a birth certificate. Early child outcome measures focused on height-for-age z-scores (HAZ), weight-for-age z-scores (WAZ), weight-for-height z-scores (WHZ), and standardized scores of the Early Childhood Development Index (ECDI) for a subsample of children aged 36–59 months. We used linear regression models with country fixed effects to estimate the relationship between birth registration and child outcomes. In fully adjusted models, we controlled for a variety of child, caregiver, household, and access to child services covariates, including cluster-level fixed effects. Results: In the total sample, 34.7% of children aged 0–59 months did not possess a birth certificate. After controlling for covariates, not owning a birth certificate was associated with lower HAZ (β = − 0.18; 95% CI: -0.23, − 0.14), WAZ (β = − 0.10, 95% CI: -0.13, − 0.07), and ECDI z-scores (β = − 0.10; 95% CI: -0.13, − 0.07) among children aged 36–59 months. Conclusion: Our findings document links between birth registration and children’s early growth and development outcomes. Efforts to increase birth registration may be promising for promoting early childhood development in LMICs